Our lab, Laboratory for Vascular Morphogenesis, will be launched in October 2016 at RIKEN CDB. We aim to unravel fundamental mechanisms that regulate endothelial cell dynamics and coordination during the formation of blood vessels through sprouting angiogenesis. We use zebrafish as the model organism to observe and understand the process of angiogenesis, and employ variety methods such as live imaging at high temporal and spatial resolution, advanced fluorescent microscopy techniques, genetics and chemical biology to elucidate the mechanical and molecular mechanisms of vascular morphogenesis. The following projects are available:
1）Force generation in regulating endothelial cell dynamics and vessel morphogenesis.
2）Mechanisms controlling actomyosin activity in endothelial cells.
3）Molecular regulation of vessel lumen formation.
| References： | ||
| 1. | Gebala V, Collins R, Geudens I, Phng LK* and Gerhardt H*. Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo. NATURE CELL BIOLOGY 18 (4), 443 - 451 (2016). *equal contribution |
|
| 2. | Phng LK, Gebala V, Bentley K, Philippides A, Wacker A, Mathivet T, Sauteur L, Stanchi S, HG Belting, Affolter M, Gerhardt H. Formin-mediated actin polymerization at endothelial junctions is required for vessel lumen formation and stabilization. DEVELOPMENTAL CELL 32, 123 -132 (2015). | |
Research scientist (postdoctoral fellow)
We seek highly motivated individuals who are keen to understand endothelial cell behavior during blood vessel development. Experience in one or more of the following is desired: use of fish as a model system, cell biology and/or live imaging. In addition, the candidate should show a strong interest in advanced imaging techniques and image analyses. A good command of English is required, as all research discussions, meetings and seminars are held in English.
Applicants have to be awarded a PhD degree by the commencement date.
RIKEN Center for Developmental Biology (Port Island, Kobe, Japan)
Address: Minatojima-minamimachi 2-2-3, Chuo-ku, Kobe, Hyogo, 650-0047, Japan
Full-time position with an annually renewable contract up to 5 years based on evaluation. Salary will be commensurate with qualifications and experience. Commuting and housing allowances will be provided. Social insurance will be applied. Mandatory membership in the RIKEN Mutual Benefit Society (RIKEN Kyosaikai). Days off include weekends, public holidays, New Year's holidays (Dec. 29 - Jan 3), and RIKEN Foundation Day.
These and other provisions are in accordance with RIKEN regulations.
Required application package
1.The application package should include 1) A cover letter that states, prior research achievements, your scientific interests, reasons for applying and a brief proposition about research project in our lab. 2) The curriculum vitae with photo and a list of publications.
2.Separately from above documents, please provide two references. References should be obtained from your current supervisor. (If a reference from a person mentioned above is not available, a reference from someone who knows your research abilities well will be accepted.) These letters should be directly sent to Kobe Human Resources Section from referees by email or by post.
All documents should be prepared in English.
Application package is not returnable.
Deadline
Positions will remain open until suitable candidates are appointed.
Handling Personal Data
Handling of Personal Data: All private data sent to RIKEN in application for employment is handled in strict confidentiality, and such data is not utilized for any other purpose or disclosed to any third party.
Applicationdocuments will not be returned.
Commencing date is from October 2016 onward. Negotiable.
Send application to
Application package and recommendation letters should be sent to:
Kobe Human Resources Section,
RIKEN Kobe branch, Kobe Administrative Division
2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan
Email: kobe-jobs[at]riken.jp (Replace "[at]" with "@".)
Contact Information
For further inquiries, please email:
Li-Kun Phng, PhD.
Email: likun.phng[at]ncvc.go.jp (Replace "[at]" with "@".)
